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KMID : 1200020150390060468
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Diabetes & Metabolism Journal
2015 Volume.39 No. 6 p.468 ~ p.477
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Maturity-Onset Diabetes of the Young: What Do Clinicians Need to Know?
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:Kim Sung-Hoon
저자없음:No authors listed
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Abstract
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Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes that is characterized by an early onset, autosomal dominant mode of inheritance and a primary defect in pancreatic β-cell function. MODY represents less than 2% of all diabetes cases and is commonly misdiagnosed as type 1 or type 2 diabetes mellitus. At least 13 MODY subtypes with distinct genetic etiologies have been identified to date. A correct genetic diagnosis is important as it often leads to personalized treatment for those with diabetes and enables predictive genetic testing for their asymptomatic relatives. Next-generation sequencing may provide an efficient method for screening mutations in this form of diabetes as well as identifying new MODY genes. In this review, I discuss a current update on MODY in the literatures and cover the studies that have been performed in Korea.
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KEYWORD
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Diagnosis, Maturity-onset diabetes of the young, Personalized treatment
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